Inospiron 25 mg

Oedema and ascites in cirrhosis of the liver, malignant ascites and nephrotic syndrome. Congestive heart failure. Primary hyperaldosteronism and resistant hypertension.

Spironolactone is a competitive antagonist of aldosterone in the distal renal tubule. It increases excretion of sodium and water while retaining potassium and magnesium.

Oedema and ascites: 100-200 mg daily, increased if needed to 400 mg daily. Heart failure: 25 mg once daily, increased if needed to 50 mg once daily. Take with food. Child: dose by body weight as directed by the physician.

Raised blood potassium, breast enlargement or tenderness in men, menstrual irregularity, gastrointestinal upset, drowsiness, dizziness and leg cramps.

Monitor serum potassium and kidney function, especially in the elderly and in renal impairment. Avoid potassium supplements and use with caution with ACE inhibitors, angiotensin receptor blockers and NSAIDs.

Raised blood potassium, anuria, severe renal impairment, Addison's disease and hypersensitivity to spironolactone.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.