Losectil IV 40 mg

Gastric and duodenal ulcer, gastro-oesophageal reflux disease (GERD) and reflux oesophagitis, acid-related dyspepsia, treatment and prevention of NSAID-associated ulcer, Zollinger-Ellison syndrome, and eradication of Helicobacter pylori in combination with antibiotics.

Omeprazole suppresses gastric acid secretion by irreversibly inhibiting the hydrogen-potassium ATPase enzyme (the proton pump) of the gastric parietal cell. It reduces both basal and stimulated acid secretion.

Adult: 20 mg once daily before a meal for 4 to 8 weeks; 40 mg once daily in severe or resistant cases. H. pylori eradication: 20 mg twice daily with antibiotics for 7 to 14 days. Zollinger-Ellison syndrome: initially 60 mg once daily, adjusted according to response. Injection: 40 mg once daily by slow intravenous injection or infusion when oral treatment is not possible. Child: dose according to body weight, as directed by the physician.

Headache, diarrhoea, constipation, abdominal pain, nausea, vomiting and flatulence. Rarely skin rash and dizziness.

Exclude gastric malignancy before treatment when alarm symptoms are present. Use with caution in severe liver impairment. Long-term use may lower magnesium and vitamin B12 levels and increase the risk of bone fracture. May reduce the effect of clopidogrel. Use in pregnancy and breast-feeding only if advised by the physician.

Hypersensitivity to omeprazole or other proton pump inhibitors. Concomitant use with nelfinavir.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.