Neulyn 400 mg

Chronic asthma. Reversible airway obstruction in chronic bronchitis and emphysema (COPD).

Theophylline is a xanthine that relaxes bronchial smooth muscle, mainly by inhibiting phosphodiesterase and blocking adenosine receptors. It has a narrow margin between the effective and the toxic dose.

Sustained release tablet, adult: 200 mg every 12 hours, increased according to response to 400 mg every 12 hours, or as directed by the physician. Swallow whole; do not crush or chew.

Nausea, vomiting, stomach irritation, headache, insomnia, palpitations and fast heart rate. Arrhythmias and convulsions may occur with overdose.

Use with caution in heart disease, hypertension, epilepsy, peptic ulcer, hyperthyroidism, liver disease, fever and the elderly. Ciprofloxacin, erythromycin and cimetidine raise its blood level; smoking lowers it. Do not change brand without advice.

Hypersensitivity to theophylline or other xanthines, and acute porphyria.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.