Nintoin SR 100 mg

Capsule

Incepta Pharmaceuticals Ltd.

Therapeutic Class: Urinary Antibacterial

Indications

Treatment and prevention of uncomplicated lower urinary tract infections (acute cystitis).

Pharmacology

Nitrofurantoin is reduced by bacterial enzymes to reactive intermediates that damage bacterial DNA, ribosomal proteins and other macromolecules. It is concentrated in urine and is active against most urinary pathogens including E. coli.

Dosage & Administration

Adult: 50 mg four times daily for 3-7 days (up to 100 mg four times daily if needed); sustained-release capsule 100 mg twice daily. Prophylaxis: 50-100 mg at night. Child over 3 months: 3 mg/kg daily in 4 divided doses. Take with food or milk.

Side Effects

Nausea, vomiting, loss of appetite, headache, dizziness; urine may turn dark yellow or brown. Rarely: acute or chronic lung reactions, peripheral neuropathy, hepatitis, allergic reactions.

Precautions & Warnings

Use with caution in diabetes, anaemia, vitamin B deficiency, electrolyte imbalance and lung or liver disease. In long-term use monitor lung and liver function; stop if breathlessness or tingling of the hands or feet develops. Complete the full prescribed course. Use only on the prescription of a registered physician.

Contraindications

Significant renal impairment (eGFR below 45 ml/minute), G6PD deficiency, acute porphyria, infants under 3 months, and pregnancy at term (risk of neonatal haemolysis).

Storage Conditions

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.

This information is for reference only. Always consult a qualified doctor or pharmacist before taking any medicine.