Nocandia 100 mg

Fungal skin infections (tinea corporis, cruris, pedis and manuum), pityriasis versicolor, vulvovaginal and oropharyngeal candidiasis, fungal nail infections (onychomycosis), and systemic fungal infections such as aspergillosis and histoplasmosis.

Itraconazole inhibits fungal cytochrome P450 14-alpha-demethylase, blocking ergosterol synthesis in the fungal cell membrane. It is highly lipophilic and persists in skin and nails for weeks after treatment stops.

Vulvovaginal candidiasis: 200 mg twice daily for 1 day. Tinea corporis or cruris: 100 mg once daily for 15 days, or 200 mg once daily for 7 days. Tinea pedis or manuum: 100 mg once daily for 30 days; pityriasis versicolor: 200 mg once daily for 7 days. Nail infection: 200 mg once daily for 3 months, or pulse courses of 200 mg twice daily for 7 days each month. Take capsules immediately after a full meal.

Nausea, abdominal pain, diarrhoea, headache, skin rash. Rarely: liver toxicity, heart failure, peripheral neuropathy.

Monitor liver function if treatment lasts longer than one month or if symptoms of hepatitis appear. Antacids and acid-suppressing drugs reduce absorption of the capsules. It has many drug interactions; tell the physician about all other medicines. Use as directed by a registered physician and complete the advised course.

Hypersensitivity to itraconazole; ventricular dysfunction or history of heart failure (except in life-threatening infections); pregnancy. Concomitant use with certain drugs such as simvastatin, lovastatin, cisapride, pimozide, quinidine, oral midazolam and ergot alkaloids.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.