Fusid Plus 40 mg + 50 mg

Resistant oedema associated with secondary hyperaldosteronism, as in chronic congestive heart failure and cirrhosis of the liver with ascites.

Furosemide, a loop diuretic, increases excretion of salt and water but causes potassium loss; spironolactone antagonises aldosterone and retains potassium. Together they produce an additive diuretic effect while limiting potassium loss.

Adult: 1 to 4 tablets of furosemide 20 mg + spironolactone 50 mg daily, according to response. The higher strength (40 mg + 50 mg) is used as directed by the physician.

Disturbance of blood potassium and sodium, dehydration, low blood pressure, dizziness, gastrointestinal upset, breast enlargement in men, raised uric acid and raised blood sugar.

Monitor electrolytes and kidney function regularly. Use with caution in diabetes, gout, the elderly and with ACE inhibitors, NSAIDs or digoxin. Avoid potassium supplements.

Anuria, severe renal impairment, raised blood potassium, severe low sodium or dehydration, Addison's disease, pregnancy, breast-feeding and hypersensitivity to either component or to sulfonamides.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.