Osartil 50 mg

Hypertension, including patients with left ventricular hypertrophy (to reduce the risk of stroke). Kidney disease in type 2 diabetes with hypertension (diabetic nephropathy). Chronic heart failure when ACE inhibitors are not tolerated.

Losartan is an angiotensin II receptor blocker (ARB). By blocking the AT1 receptor it prevents the vasoconstrictor and aldosterone-releasing effects of angiotensin II, so blood vessels relax and blood pressure falls. It does not usually cause the dry cough seen with ACE inhibitors.

Adult: 50 mg once daily; may be increased to 100 mg once daily. Elderly over 75 years, volume depletion or hepatic impairment: start with 25 mg once daily. Heart failure: start with 12.5 mg once daily and increase gradually. May be taken with or without food.

Dizziness, low blood pressure, fatigue, raised blood potassium and changes in kidney function. Angioedema is rare.

Monitor kidney function and serum potassium, especially in renal impairment, renal artery stenosis, heart failure and the elderly. Avoid potassium supplements and potassium-sparing diuretics unless advised. Not recommended during breast-feeding.

Pregnancy, hypersensitivity to losartan, severe hepatic impairment, and use with aliskiren in patients with diabetes or renal impairment.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.