Indever 40 mg

Prophylaxis of migraine; anxiety with symptoms such as palpitation, sweating and tremor; essential tremor. Also used in hypertension, angina, arrhythmias and as an adjunct in thyrotoxicosis.

Propranolol blocks beta-1 and beta-2 adrenergic receptors, reducing heart rate, the force of contraction and blood pressure, and blunting the physical symptoms of anxiety.

Migraine prophylaxis and essential tremor: Adult: initially 40 mg 2 to 3 times daily; usual maintenance dose 80 mg to 160 mg daily. Anxiety with palpitation, sweating or tremor: 40 mg once daily, increased if necessary to 40 mg 3 times daily. Hypertension: initially 80 mg 2 times daily; usual maintenance dose 160 mg to 320 mg daily.

Fatigue, cold hands and feet, slow heart rate, dizziness, sleep disturbance, nausea and bronchospasm.

To be used on the advice of a registered physician. Must not be stopped abruptly, especially in ischaemic heart disease; the dose should be reduced gradually. In diabetes it may mask the symptoms of low blood sugar. Use with caution in heart failure, hepatic or renal impairment and in pregnancy.

Asthma or history of bronchospasm, uncontrolled heart failure, marked bradycardia, second- or third-degree heart block, sick sinus syndrome, cardiogenic shock, hypotension, severe peripheral arterial disease and untreated phaeochromocytoma.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.