Pantonix 40 mg

Gastric and duodenal ulcer, gastro-oesophageal reflux disease and reflux oesophagitis, prevention of NSAID-associated ulcer, Zollinger-Ellison syndrome, and eradication of Helicobacter pylori in combination with antibiotics.

Pantoprazole is a substituted benzimidazole that suppresses gastric acid secretion by irreversibly inhibiting the hydrogen-potassium ATPase enzyme (the proton pump) of the gastric parietal cell.

Gastric ulcer and reflux oesophagitis: 40 mg once daily before breakfast for 4 to 8 weeks; duodenal ulcer 40 mg once daily for 2 to 4 weeks. Mild GERD, maintenance and prevention of NSAID-associated ulcer: 20 mg once daily. H. pylori eradication: 40 mg twice daily with antibiotics for 7 to 14 days. Zollinger-Ellison syndrome: initially 80 mg daily, adjusted according to response. Injection: 40 mg once daily by slow intravenous injection or infusion when oral treatment is not possible.

Headache, diarrhoea, constipation, abdominal pain, flatulence, nausea and vomiting. Rarely dizziness, skin rash and raised liver enzymes.

Exclude gastric malignancy before treatment when alarm symptoms are present. Use with caution in severe liver impairment. Long-term use may lower magnesium and vitamin B12 levels and increase the risk of bone fracture. Use in pregnancy and breast-feeding only if advised by the physician.

Hypersensitivity to pantoprazole or other proton pump inhibitors.

Store below 30°C in a cool, dry place, away from light. Keep out of the reach of children.